Yang H, Shao N, Holmström A, Zhao X, Chour T, Chen H, Itzhaki I, Wu H, Ameen M, Cunningham NJ, Tu C, Zhao MT, Tarantal AF, Abilez OJ, Wu JC. Transcriptome Analysis of Non-Human Primate Induced Pluripotent Stem Cell-Derived Cardiomyocytes in 2D Monolayer Culture versus 3D Engineered Heart Tissue. Cardiovasc Res. 2020. [Epub ahead of print] PubMed PMID: 33002105.
Li LL, Guo QJ, Lou HY, Liang JH, Yang Y, Xing X, Li HT, Han J, Shen S, Li H, Ye H, Di Wu H, Cui B, Wang SQ. Nanobar Array Assay Revealed Complementary Roles of BIN1 Splice Isoforms in Cardiac T-Tubule Morphogenesis. Nano Lett. 2020. PubMed PMID: 32787151.
Liu Q*, Wu H*, Luo QJ, Jiang C, Duren Z, Bortle KV, Zhao MT, Zhao B, Liu J, Marciano DP, Lee-McMullen B, Zhu C, Narasimha AM, Gruber JJ, Lipchik AM, Guo H, Watson NK, Tsai MS, Furihata T, Tian L, Wei E, Li Y, Steinmetz LM, Wong WH, Kay MA, Wu JC, Snyder MP. Tyrosine Kinase Inhibitors Induce Mitochondrial Dysfunction During Cardiomyocyte Differentiation Through Alteration of GATA4-Mediated Networks. BioRxiv. 2020.
Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S, Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M, Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu JC, Sluijter JPG, Wu SM. Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes. Cell Stem Cell. 2020. PubMed PMID: 32619518; PubMed Central PMCID: PMC7334437.
2019
Wnorowski A, Sharma A, Chen H, Wu H, Shao NY, Sayed N, Liu C, Countryman S, Stodieck LS, Rubins KH, Wu SM, Lee PHU, Wu JC. Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. Stem Cell Reports. 2019. PubMed PMID: 31708475; PubMed Central PMCID: PMC6915842.
Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC. Modeling Diastolic Dysfunction in Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Hypertrophic Cardiomyopathy Patients. Eur Heart J. 2019. PubMed PMID: 31219556.
Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S. RRAD Mutation Causes Electrical and Cytoskeletal Defects in Cardiomyocytes Derived from a Familial Case of Brugada Syndrome. Eur Heart J. 2019. PubMed PMID: 31114854; PubMed Central PMCID: PMC6769825.
Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A Computational Model of Induced Pluripotent Stem-Cell Derived Cardiomyocytes Incorporating Experimental Variability from Multiple Data Sources. J Physiol. 2019. PubMed PMID: 31278749; PubMed Central PMCID: PMC6767694.
Zhang H, Tian L, Shen M, Tu C, Wu H, Gu M, Paik DT, Wu JC. Generation of Quiescent Cardiac Fibroblasts from Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis. Circ Res. 2019. PubMed PMID: 31288631; PubMed Central PMCID: PMC6768436.
Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC. Activation of PDGF Pathway Links LMNA Mutation to Dilated Cardiomyopathy. Nature. 2019. PubMed PMID: 31316208; PubMed Central PMCID: PMC6779479.
Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell. 2019. PubMed PMID: 30880024; PubMed Central PMCID:
Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. An Orange Calcium-Modulated Bioluminescent Indicator for Non-Invasive Activity Imaging. Nat Chem Biol. 2019. PubMed PMID: 30936501; PubMed Central PMCID: PMC6563924.
Tang L, Yao F, Wang H, Wang X, Shen J, Dai B, Wu H, Zhou D, Guo F, Wang J, Li T, Wang H, Gong T, Su J, Wang L, Liang P. Inhibition of TRPC1 Prevents Cardiac Hypertrophy via NF-κB Signaling Pathway in Human Pluripotent Stem Cell-Derived Cardiomyocytes. J Mol Cell Cardiol. 2019. PubMed PMID: 30423318.
2018
Ma N, Zhang JZ, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC. Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells. Circulation. 2018. PubMed PMID: 29914921; PubMed Central PMCID: PMC6298866.
Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018. PubMed PMID: 30464173; PubMed Central PMCID: PMC6249224.
Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC. SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation. Cell Stem Cell. 2018. PubMed PMID: 29499155; PubMed Central PMCID: PMC5929163.
Qin X, Chen H, Yang H, Wu H, Zhao X, Wang H, Chour T, Neofytou E, Ding D, Daldrup-Link H, Heilshorn SC, Li K, Wu JC. Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles. Adv Funct Mater. 2018. PubMed PMID: 30473658; PubMed Central PMCID: PMC6247950.
2017
Lee WH, Chen WY, Shao NY, Xiao D, Qin X, Baker N, Bae HR, Wei TT, Wang Y, Shukla P, Wu H, Kodo K, Ong SG, Wu JC. Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human Embryonic Stem Cell- versus Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells. 2017. PubMed PMID: 28710827; PubMed Central PMCID: PMC5918285.
Chamberland S, Yang HH, Pan MM, Evans SW, Guan S, Chavarha M, Yang Y, Salesse C, Wu H, Wu JC, Clandinin TR, Toth K, Lin MZ, St-Pierre F. Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators. Elife. 2017. PubMed PMID: 28749338; PubMed Central PMCID: PMC5584994.
Serpooshan V, Chen P, Wu H, Lee S, Sharma A, Hu DA, Venkatraman S, Ganesan AV, Usta OB, Yarmush M, Yang F, Wu JC, Demirci U, Wu SM. Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue. Biomaterials. 2017. PubMed PMID: 28376365; PubMed Central PMCID: PMC5446052.
Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Circ Res. 2017. PubMed PMID: 28246128; PubMed Central PMCID: PMC5429194.
Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Cell Stem Cell. 2017. PubMed PMID: 28089908; PubMed Central PMCID: PMC5508733.
Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017. PubMed PMID: 28202772; PubMed Central PMCID: PMC5409837.
2016
Liang P*, Sallam K*, Wu H*, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016. PubMed PMID: 27810048; PubMed Central PMCID: PMC5373649.
Lee J, Jung SM, Ebert AD, Wu H, Diecke S, Kim Y, Yi H, Park SH, Ju JH. Generation of Functional Cardiomyocytes from the Synoviocytes of Patients with Rheumatoid Arthritis via Induced Pluripotent Stem Cells. Sci Rep. 2016. PubMed PMID: 27609119; PubMed Central PMCID: PMC5016736.
Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 2016. PubMed PMID: 27545504; PubMed Central PMCID: PMC5087997.
Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. 2016. PubMed PMID: 27114035; PubMed Central PMCID: PMC4874838.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med. 2016. PubMed PMID: 27089514; PubMed Central PMCID: PMC5086256.
He C, Hu H, Wilson KD, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC. Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation in Human Fetal and Adult Hearts. Circ Cardiovasc Genet. 2016. PubMed PMID: 26896382; PubMed Central PMCID: PMC4862831.
Burridge PW, Diecke S, Matsa E, Sharma A, Wu H, Wu JC. Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol. 2016. PubMed PMID: 25690476; PubMed Central PMCID: PMC4962608.
2015
Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015. PubMed PMID: 26095046; PubMed Central PMCID: PMC4546705.
Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. Eur Heart J. 2015. PubMed PMID: 25368203; PubMed Central PMCID: PMC4381134.
2014
Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med. 2014. PubMed PMID: 25253673; PubMed Central PMCID: PMC4215699.
Sharma A, Marceau C, Hamaguchi R, Burridge PW, Rajarajan K, Churko JM, Wu H, Sallam KI, Matsa E, Sturzu AC, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circ Res. 2014. Epub 2014 Jul 11. PubMed PMID: 25015077; PubMed Central PMCID: PMC4149868.
Wang Y*, Liang P*, Lan F*, Wu H*, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. J Am Coll Cardiol. 2014. PubMed PMID: 25082577; PubMed Central PMCID: PMC4149735.
2013
Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers DM, Wu JC. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013. PubMed PMID: 24030418; PubMed Central PMCID: PMC3855862.
Han J, Wu H, Wang Q, Wang S. Morphogenesis of T-tubules in heart cells: the role of junctophilin-2. Sci China Life Sci. 2013. PubMed PMID: 23749380.
Zhang HB, Li RC, Xu M, Xu SM, Lai YS, Wu HD, Xie XJ, Gao W, Ye H, Zhang YY, Meng X, Wang SQ. Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure. Cardiovasc Res. 2013. PubMed PMID: 23405000.
Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ. In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice. Circ Res. 2013. PubMed PMID: 23307820; PubMed Central PMCID: PMC3622206.
2012
Xu M*, Wu HD*, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JJ, Gao W, Han QD, Zhang YY, Wang XJ, Meng X, Wang SQ. Mir-24 regulates junctophilin-2 expression in cardiomyocytes. Circ Res. 2012. Epub 2012 Aug 13. PubMed PMID: 22891046; PubMed Central PMCID: PMC3611051.
Wu HD, Xu M, Li RC, Guo L, Lai YS, Xu SM, Li SF, Lü QL, Li LL, Zhang HB, Zhang YY, Zhang CM, Wang SQ. Ultrastructural remodelling of Ca(2+) signalling apparatus in failing heart cells. Cardiovasc Res. 2012. PubMed PMID: 22707157; PubMed Central PMCID: PMC3422078.
Wu H, Wang S, Xu M, Zhang H. The structural and functional coupling between plasma membrane and sarcoplasmic reticulum in cardiac cells and its remodeling in heart diseases. Chinese Bulletin of Life Science. 2011; 23(11):1088-94.
